BPC-157 (10 mg)

BPC-157 (Body Protection Compound-157) is a synthetic pentadecapeptide consisting of 15 amino acids, originally discovered as a stable fragment of a protective protein found in gastric juice. It has since been synthesized for research purposes, where it has been extensively studied for its unique activity in experimental models of tissue protection, repair, and inflammatory regulation.

Unlike many peptide analogs associated with hormonal or endocrine pathways, BPC-157 is primarily examined in the context of cellular regeneration and protective effects across musculoskeletal, gastrointestinal, vascular, and nervous system models.

Chemical & Structural Features

• Sequence: Gly–Glu–Pro–Pro–Pro–Gly–Lys–Pro–Ala–Asp–Asp–Ala–Gly–Leu–Val
• Molecular Formula: C₆₂H₉₈N₁₆O₂₂
• Molecular Weight: ~1,419.5 Da
• Stability: Exhibits high resistance to enzymatic breakdown and gastric degradation, allowing it to remain intact under diverse laboratory conditions.

Research Insights

Laboratory and preclinical studies highlight several areas of interest:

• Tissue Healing: Investigated for its ability to accelerate repair in tendons, ligaments, muscles, and skin, possibly linked to fibroblast activation, angiogenesis, and collagen deposition.
• Gastrointestinal Support: Shown to preserve mucosal integrity and protect against ulcer formation in gastric injury models.
• Vascular Modulation: Reported to influence nitric oxide (NO) signaling and VEGF pathways, promoting blood vessel stability and repair in ischemic models.
• Neural and Organ Protection: Examined for potential protective effects in models of brain, nerve, liver, and kidney injury under stress conditions.
• Inflammation & Oxidative Balance: Studied for its ability to regulate inflammatory cytokines and mitigate oxidative stress markers, aligning with observations of analgesic-like properties in animal research.

Overall, BPC-157 continues to attract research interest due to its broad experimental profile spanning regeneration, vascular biology, and inflammation regulation.

Citations

1. PubChem, “BPC‑157 Compound Summary,” NCBI PubChem, CID 9941957. BPC‑157 Molecular Structure
2. Peptide Sciences, “What is BPC‑157 Peptide?” BPC‑157 Molecular Structure
3. Seiwerth S, et al. “Stable Gastric Pentadecapeptide BPC‑157 and Wound Healing.” Front Pharmacol. 2021;12:627533. BPC‑157 Molecular Structure
4. Staresinic M, et al. “BPC‑157 accelerates healing of rat Achilles tendon.” J Orthop Res. 2003;21(6):976–983. BPC‑157 Molecular Structure
5. Chang CH, et al. “BPC‑157 promotes tendon healing.” J Appl Physiol. 2011;110(3):774–780. BPC‑157 Molecular Structure
6. “Stable gastric pentadecapeptide BPC‑157: GI therapy.” Curr Pharm Des. 2011. BPC‑157 Molecular Structure
7. “BPC‑157 promotes angiogenesis via VEGFR2 and NO.” BPC‑157 Molecular Structure
8. Peptides.org, “BPC‑157 Reviews and Safety.” BPC‑157 Molecular Structure
9. Cerovecki T, et al. “BPC‑157 improves ligament healing in rats.” J Orthop Res. 2010;28(9):1155–1161. BPC‑157 Molecular Structure